Kenyon had a crisis of faith and left the faith for 2 1/2 years prior returning to faith in 1893. Although desiring to be an actor, Kenyon earned a living as a piano and organ salesperson. In an attempt to hone his acting skills, Kenyon attended the Emerson School of Oratory in Boston for one year in 1892 studying acting.
Kenyon first married Evva Spurling. The two were married on May 8, 1893. Shortly afterward, Kenyon attended the services of Clarendon Street Baptist Church led by pastor Adoniram Judson (A.J.) Gordon. At this service, Kenyon and his wife rededicated their lives to the Lord. Later that year, Kenyon joined the Free Will Baptists and became a pastor at a small church in Elmira, New York. In 1898, Kenyon opened Bethel Bible Institute in Spencer, Massachusetts, which remained in operation until 1923. He was its president for twenty-five years.
The school later moved to Providence, Rhode Island and became Providence Bible Institute. It later became Barrington College and merged with Gordon College, which was named after one of Kenyon's many mentors, A.J. Gordon. Evva Kenyon died in 1914. Subsequently, Kenyon married Alice M. Whitney and had a son and a daughter with her.
In 1948, E. W. Kenyon died.